Biofilm maturity studies indicate sharp debridement opens a time-dependent therapeutic window

Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window.

OBJECTIVE To investigate the hypothesis that newly formed wound biofilms (or bioburdens) are more susceptible to antimicrobial treatment. METHOD Four separate and distinct models were performed by four separate biofilm research laboratories to evaluate the resistance of biofilms to antimicrobial treatments over time. These included a drip-flow biofilm model along with a hydrodebridement study...

Electron spectroscopy: a new window opens.

[Therapeutic time window in ischemic stroke].

近年,脳梗塞の治療では心筋梗塞の治療と同様に早 期診断・早期治療の重要性が叫ばれ,心筋梗塞が “Heart Attack”と呼ばれ可急的速やかに治療され一命 をとりとめるように,脳梗塞も“Brain Attack”と捉え 同様に速やかに治療を行い,後遺症を最小限にくいと めることの重要性が認識されつつある.脳虚血が発症 して脳血流が遮断されると脳組織は数時間で不可逆性 の変化をきたし壊死に陥って梗塞となる.ひとたび脳 梗塞に罹患すると片麻痺や言語障害などの神経症候, 記憶・記銘力の低下や情緒障害などの精神症状,さら にQOLの低下や痴呆症などの後遺症に苦しむことに なり社会的生命を失うことにもなる. 近年CT(computed tomography),MRI・A(magnetic resonance imaging・angiography),SPECT(single photon e...

Organogenesis of kidney and endocrine pancreas: the window opens.

Growing new organs in situ by implanting developing animal organ primordia (organogenesis) represents a novel solution to the problem of limited supply for human donor organs that offers advantages relative to transplanting embryonic stem (ES) cells or xenotransplantation of developed organs. Successful transplantation of organ primordia depends on obtaining them at defined windows during embry...

Erectile dysfunction and coronary artery disease: the cardiac window opens.

There is now a large body of evidence linking erectile dysfunction (ED) and coronary artery disease (CAD) (1). The common pathophysiology is endothelial dysfunction and with ED being recognised as a predominantly vascular disease the recognition that ED may present 2–5 years before cardiac symptoms has opened the window of opportunity to use ED as a marker of silent CAD and a means, therefore, ...